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PubMed · 10852132

The thymus and negative selection.

H Kishimoto·J Sprent
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Abstract

Self-tolerance induction is largely a reflection of negative selection (deletion) of autoreactive T cells in the thymus. Evidence is presented that negative selection occurs at a relatively late stage of thymocyte differentiation and affects a population of semimature HSA(hi) CD4+8- cells found in the medulla. Negative selection involves a number of cell-surface molecules on T cells, including Fas, CD28, CD5, and CD43. These molecules appear to act in consort, thereby ensuring that negative selection is highly efficient.

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AnimalsCell DifferentiationHumansReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesThymus GlandJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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H Kishimoto, J Sprent. 2000. The thymus and negative selection.. https://doi.org/10.1385/ir%3A21%3A2-3%3A315

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