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PubMed · 10867030

Specific cellular responses to alpha-tocopherol.

A Azzi·I Breyer·M Feher·M Pastori·R Ricciarelli·S Spycher·M Staffieri·A Stocker·S Zimmer·J M Zingg
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Abstract

In the last 10 years precise cellular functions of alpha-tocopherol, some of which are independent of its antioxidant/radical-scavenging ability, have been revealed. Absorption of alpha-tocopherol from the gut is a selective process. Other tocopherols are not absorbed or are absorbed to a lesser extent. At the post-translational level, alpha-tocopherol inhibits protein kinase C and 5-lipoxygenase and activates protein phosphatase 2A and diacylglycerol kinase. Some genes [platelet glycoprotein IV/thrombospondin receptor/class B scavenger receptor (CD36), alpha-tocopherol transfer protein (alpha-TTP), alpha-tropomyosin, connective tissue growth factor and collagenase] are affected by alpha-tocopherol at the transcriptional level. alpha-Tocopherol also inhibits cell proliferation, platelet aggregation, monocyte adhesion and the oxygen burst in neutrophils. Other antioxidants, such as beta-tocopherol and probucol, do not mimic these effects, suggesting a nonantioxidant, alpha-tocopherol-specific molecular mechanism.

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AnimalsCell AdhesionCell DivisionDiacylglycerol KinaseEnzyme ActivationHumansLipoxygenase InhibitorsPhosphoprotein PhosphatasesPlatelet AggregationProtein Kinase CProtein Phosphatase 2Protein Processing, Post-TranslationalReactive Oxygen SpeciesTranscription, GeneticVitamin EJournal ArticleResearch Support, Non-U.S. Gov'tReview

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A Azzi, I Breyer, M Feher, M Pastori, R Ricciarelli, S Spycher, M Staffieri, A Stocker, S Zimmer, J M Zingg. 2000. Specific cellular responses to alpha-tocopherol.. https://doi.org/10.1093/jn%2F130.7.1649

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