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PubMed · 10873621

Structure-activity relationships for selected sulfur-rich antithrombotic compounds.

J A MacDonald·R F Langler
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Abstract

We assessed the antithrombotic activity of some simple organosulfur compounds which have some of the functionality found in the disulfide ajoene, a pharmacologically active compound isolated from garlic. The results establish that antithrombotic activity is associated with disulfides directly attached to a phenyl ring and is further enhanced by an alpha-sulfonyl group. CH(3)SO(2)CH(2)SSPh proved to be a potent inhibitor of platelet aggregation with an IC(50) of 5 microM.

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DisulfidesFibrinolytic AgentsGarlicHumansIn Vitro TechniquesPlant ExtractsPlants, MedicinalPlatelet AggregationPlatelet Aggregation InhibitorsStructure-Activity RelationshipSulfoxidesSulfurThrombinComparative StudyJournal Article

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BibTeXRIS

J A MacDonald, R F Langler. 2000-07-05. Structure-activity relationships for selected sulfur-rich antithrombotic compounds.. https://doi.org/10.1006/bbrc.2000.2950

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