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Diagnostic test needs for evaluating antituberculosis vaccines.

T M Shinnick
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Abstract

To aid in the evaluation of preexposure and postinfection vaccines to prevent tuberculosis, diagnostic tests are needed that can clearly distinguish immunologic protection from vaccine failure in a timely manner. The currently available tests to detect infected persons (tuberculin skin-test) and confirm active disease (conventional culture methods) have limitations in specificity, sensitivity, or timeliness. Research to identify (1) surrogate markers of infection, disease, or protection and (2) stage-specific antigens or immune responses holds some promise for the development of new tests that can distinguish the various outcomes of an infection or a vaccination.

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BCG VaccineHumansMycobacterium tuberculosisTreatment OutcomeTuberculin TestTuberculosis, PulmonaryJournal ArticleReview

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BibTeXRIS

T M Shinnick. 2000. Diagnostic test needs for evaluating antituberculosis vaccines.. https://doi.org/10.1086/313873

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