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PubMed · 10878571

The structure and function of HFE.

H Drakesmith·A Townsend
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Abstract

The iron overload disease hereditary haemochromatosis (HH) occurs in about 1 in 300 Caucasians; the protein mutated in this disorder is termed HFE.(1) HFE is homologous to major histocompatibility complex (MHC) class I proteins, but unlike MHC class I molecules, HFE does not present peptides to T cells.(2) The transferrin receptor (TfR) is a ligand for HFE, and the crystal structure of the HFE-TfR complex has been determined.(3) The many interesting features of this structure illustrate the diverse roles of the MHC fold in nature and clarify how HFE affects TfR function. Whether the interaction between HFE and TfR explains the pathogenesis of HH is not so clear.

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HLA AntigensHemochromatosisHemochromatosis ProteinHistocompatibility Antigens Class IHumansIronMembrane ProteinsMutationReceptors, TransferrinJournal ArticleReview

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H Drakesmith, A Townsend. 2000. The structure and function of HFE.. https://doi.org/10.1002/1521-1878(200007)22%3A7%3C595%3A%3Aaid-bies1%3E3.0.co%3B2-e

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