Dynamical complexity and temporal plasticity in pancreatic beta-cells.

R Bertram; A Sherman

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PubMed · 10878861

Dynamical complexity and temporal plasticity in pancreatic beta-cells.

R Bertram·A Sherman

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Abstract

We discuss some of the biological and mathematical issues involved in understanding and modelling the bursting electrical activity in pancreatic beta-cells. These issues include single-cell versus islet behaviour, parameter heterogeneity, channel noise, the effects of hormones, neurotransmitters, and ions, and multiple slow biophysical processes. Some of the key experimental and modelling studies are described, and some of the major open questions are discussed.

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Acetylcholine Animals Biological Clocks Calcium Cell Communication Cell Separation Electrophysiology Glucose Humans Ion Channels Islets of Langerhans Models, Biological Nonlinear Dynamics Journal Article Research Support, U.S. Gov't, Non-P.H.S.Review

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R Bertram, A Sherman. 2000. Dynamical complexity and temporal plasticity in pancreatic beta-cells.. https://pubmed.ncbi.nlm.nih.gov/10878861/

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