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PubMed · 10879049

[p53 transgenic and knockout mice].

H Oda
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Abstract

Li-Fraumeni syndrome(LFS) and its relation to the p53 gene and p53 gene transgenic and targeting mice are reviewed. LFS is a hereditary cancer-prone syndrome mainly with germ line mutation of p53 gene. p53 deficient mice, especially heterozygous mice, may serve as a model for human LFS, although there are several discrepancies between them. Carcinogenesis experiment using p53 deficient mice may be important to clarify the role of p53 in tumorigenesis in vivo.

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AnimalsDisease Models, AnimalGene DeletionGenes, p53Germ-Line MutationHeterozygoteHumansLi-Fraumeni SyndromeMiceMice, KnockoutMice, TransgenicEnglish AbstractJournal ArticleReview

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H Oda. 2000. [p53 transgenic and knockout mice].. https://pubmed.ncbi.nlm.nih.gov/10879049/

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