A molecular NAND gate based on Watson-Crick base pairing.

H T Baytekin; E U Akkaya

doi:10.1021/ol005873c

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A molecular NAND gate based on Watson-Crick base pairing.

H T Baytekin·E U Akkaya

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Abstract

[reaction: see text] A DNA-binding dye, 4',6-diamidino-2-phenylindole (DAPI) signals AT base pairing with a shift in the fluorescence emission spectrum. The signaling follows W-C base-pairing rules, and both dAMP and dTMP are required for the largest spectral shift. Thus, the dye with its two phosphate receptor sites functions as a molecular NAND gate accepting nucleotides as inputs. Moreover, when the observation wavelength is changed from 470 to 411.5 nm, the gate functions in TRANSFER logic.

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Adenosine Monophosphate Base Pairing Energy Transfer Fluorescent Dyes Indoles Information Science Information Theory Intercalating Agents Thymidine Monophosphate Journal Article Research Support, Non-U.S. Gov't

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H T Baytekin, E U Akkaya. 2000-06-15. A molecular NAND gate based on Watson-Crick base pairing.. https://doi.org/10.1021/ol005873c

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