Lipoprotein A-I structure.

V Koppaka; P H Axelsen

doi:10.1016/s1050-1738(00)00024-4

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PubMed · 10881750

Lipoprotein A-I structure.

V Koppaka·P H Axelsen

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Abstract

High density lipoproteins are produced by the liver as protein-lipid complexes with a characteristic discoidal shape. A crystal structure is available for the chief protein component of these complexes, apolipoprotein A-I, but controversy about how this protein is situated with respect to the lipid components has flourished for lack of experimental techniques that can characterize protein structure in a lipid environment. New spectroscopic techniques developed to address this problem now indicate that apolipoprotein A-I is arranged as a helical belt around a bilayer of phospholipids. This is an important step towards understanding how these lipoproteins regulate cholesterol transport.

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Animals Apolipoprotein A-I Crystallography Humans Models, Molecular Spectrum Analysis Journal Article Review

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V Koppaka, P H Axelsen. 1999. Lipoprotein A-I structure.. https://doi.org/10.1016/s1050-1738(00)00024-4

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