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PubMed · 10882339

Apolipoprotein E and atherosclerosis.

L K Curtiss·W A Boisvert
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Abstract

Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease.

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AnimalsApolipoproteins EArteriosclerosisCholesterolHomeostasisHumansInflammationJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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L K Curtiss, W A Boisvert. 2000. Apolipoprotein E and atherosclerosis.. https://doi.org/10.1097/00041433-200006000-00004

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