Hepatocyte migration during liver development requires Prox1.

B Sosa-Pineda; J T Wigle; G Oliver

doi:10.1038/76996

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PubMed · 10888866

Hepatocyte migration during liver development requires Prox1.

B Sosa-Pineda·J T Wigle·G Oliver

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Abstract

Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.

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Animals Cell Movement Homeodomain Proteins Liver Mice Tumor Suppressor Proteins Prospero-Related Homeobox 1 Protein Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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B Sosa-Pineda, J T Wigle, G Oliver. 2000. Hepatocyte migration during liver development requires Prox1.. https://doi.org/10.1038/76996

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