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PubMed · 10891165

Solid-phase peptide synthesis in the reverse (N --> C) direction.

N Thieriet·F Guibé·F Albericio
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Abstract

[reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-trityl resin, an allyl ester as the temporary protecting group, and Cu(OBt)(2)/DIPCDI or HATU/DIEA as the coupling method is described. These conditions ensure good yields with minimal racemization of the C-terminal residue.

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BiochemistryPeptidesJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

N Thieriet, F Guibé, F Albericio. 2000-06-29. Solid-phase peptide synthesis in the reverse (N --> C) direction.. https://doi.org/10.1021/ol0058341

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