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PubMed · 10891661

[Radiation-induced thyroid cancers].

A Bounacer·M Schlumberger·B Caillou·A Sarasin·H G Suárez
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Abstract

Human epithelial thyroid radiation-induced tumorigenesis is the most frequent radiation-induced tumorigenic process in man. Results of different studies, concerning the molecular mecanism(s) of epithelial thyroid radiation-associated tumorigenesis show : 1) that there is not a significant difference in the frequency of activation of ras, gsp and trk proto-oncogenes between radiation-associated and < > thyroid tumors; 2) the relevant role played by RET/PTC ret proto-oncogene activating rearrangements, in the development of radiation-associated thyroid tumors originated after therapeutic radiation (mainly PTC 1) or the atomic accident of Chernobyl (mainly PTC 3) and 3) suggest that the patients who develop thyroid tumors after a history of irradiation, show a genomic instability consisting in a DNA repair defect.

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Drosophila ProteinsGTP-Binding ProteinsGenes, Tumor SuppressorGenes, rasHumansNeoplasms, Radiation-InducedProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesReceptor, Nerve Growth FactorThyroid NeoplasmsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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A Bounacer, M Schlumberger, B Caillou, A Sarasin, H G Suárez. 2000. [Radiation-induced thyroid cancers].. https://pubmed.ncbi.nlm.nih.gov/10891661/

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