An antimalarial stilbene from Artocarpus integer.

C Boonlaksiri; W Oonanant; P Kongsaeree; P Kittakoop; M Tanticharoen; Y Thebtaranonth

doi:10.1016/s0031-9422(00)00074-1

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An antimalarial stilbene from Artocarpus integer.

C Boonlaksiri·W Oonanant·P Kongsaeree·P Kittakoop·M Tanticharoen·Y Thebtaranonth

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Abstract

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 micrograms/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene , were also isolated. Structures of these compounds were deduced on the basis of their spectral data.

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Animals Antimalarials Magnetic Resonance Spectroscopy Molecular Structure Plants, Medicinal Plasmodium falciparum Spectrometry, Mass, Electrospray Ionization Stilbenes Journal Article Research Support, Non-U.S. Gov't

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C Boonlaksiri, W Oonanant, P Kongsaeree, P Kittakoop, M Tanticharoen, Y Thebtaranonth. 2000. An antimalarial stilbene from Artocarpus integer.. https://doi.org/10.1016/s0031-9422(00)00074-1

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