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PubMed · 10900481

Helminth C-type lectins and host-parasite interactions.

A Loukas·R M Maizels
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Abstract

C-type lectins (C-TLs) are a family of carbohydrate-binding proteins intimately involved in diverse processes including vertebrate immune cell signalling and trafficking, activation of innate immunity in both vertebrates and invertebrates, and venom-induced haemostasis. Helminth C-TLs sharing sequence and structural similarity with mammalian immune cell lectins have recently been identified from nematode parasites, suggesting clear roles for these proteins at the host-parasite interface, notably in immune evasion. Here, Alex Loukas and Rick Maizels review the status of helminth lectin research and suggest ways in which parasitic worms might utilize C-TLs during their life history.

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Amino Acid SequenceAnimalsHelminthiasisHelminthsHost-Parasite InteractionsHumansLectinsLectins, C-TypeMolecular Sequence DataJournal ArticleReview

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A Loukas, R M Maizels. 2000. Helminth C-type lectins and host-parasite interactions.. https://doi.org/10.1016/s0169-4758(00)01704-x

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