Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?

L Balant; J Fabre; L Loutan; H Samimi

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PubMed · 109099

Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?

L Balant·J Fabre·L Loutan·H Samimi

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Abstract

Different doses of glibenclamide and of 4-transhydroxy-glibenclamide (main metabolite in man) were administered i.p. to rats and blood glucose was measured. The comparison of the doses capable of producing a 30% decrease of the glycemia shows that 4-trans-hydroxy-glibenclamide is about 6.5 times less potent than glibenclamide in our experimental conditions.

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Animals Blood Glucose Glyburide Hydroxylation Hypoglycemic Agents Injections, Intraperitoneal Rats Time Factors Comparative Study Journal Article

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L Balant, J Fabre, L Loutan, H Samimi. 1979. Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?. https://pubmed.ncbi.nlm.nih.gov/109099/

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