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PubMed · 10925698

[Pharmacokinetically guided dose-escalation (PGDE) strategy].

T Saeki
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Abstract

When a phase I clinical trial is conducted, the dose escalation strategy is most critical. According to the results of preclinical trials, a rapid and safe dose escalation is necessary. In this regard, a pharmacokinetically guided dose-escalation (PGDE) strategy has been developed. An accelerated dose escalation is conducted by PGDE until reaching 40% target AUC. To determine the MTD of target anti-cancer agents, PGDE appears to be useful.

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AnimalsAntineoplastic AgentsCircadian RhythmClinical Trials, Phase I as TopicDose-Response Relationship, DrugHumansMiceNeoplasmsSpecies SpecificityEnglish AbstractJournal ArticleReview

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T Saeki. 2000. [Pharmacokinetically guided dose-escalation (PGDE) strategy].. https://pubmed.ncbi.nlm.nih.gov/10925698/

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