Apoptosis in multiple sclerosis.

F Zipp

doi:10.1007/s004410000179

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Apoptosis in multiple sclerosis.

F Zipp

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Abstract

Several recent studies have provided evidence that apoptosis is an important feature in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. Apoptosis presumably plays a role in the immunoregulation via activation-induced T-cell death (AICD) and in local processes of tissue damage. In this review the dual role of apoptosis in the MS pathogenesis and its relevance regarding therapeutic concepts is discussed.

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Animals Apoptosis Apoptosis Regulatory Proteins Autoimmunity Fas Ligand Protein Humans Membrane Glycoproteins Mice Models, Biological Multiple Sclerosis Signal Transduction T-Lymphocytes TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha Journal Article Research Support, Non-U.S. Gov't Review

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F Zipp. 2000. Apoptosis in multiple sclerosis.. https://doi.org/10.1007/s004410000179

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