PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 10930487

Target-specific rib biopsy using the gamma probe.

D S Fernandes·R W Aye·D J Garnett·J Denny
View original source ↗Export metadata ↓

Abstract

BACKGROUND: Intraoperative localization of rib abnormalities identified on bone scan can be deceptively difficult. Previously used techniques have had limited sensitivity and accuracy. The gamma probe can help localize these bone scan "hot spots." METHODS: Over the past 17 months, 5 patients underwent gamma-probe-directed limited rib resections following intravenous administration of Tc99m-MDP. Three patients required biopsies for suspected malignancy, and the other 2 underwent therapeutic resections for pain. The device was easy to work with following minimal training. RESULTS: Localization was excellent, limiting the extent of surgery needed. Comparison with rib counting and preoperative bone scan localization showed a discrepancy of up to 13 cm. Sensitivity and accuracy were each 100%. CONCLUSIONS: The gamma probe offers a simple and significant advance in the performance of rib biopsies for nonpalpable lesions.

Explore related subjects

BiopsyBone NeoplasmsFractures, UnunitedGamma CamerasHumansMonitoring, IntraoperativePneumothoraxRadionuclide ImagingReproducibility of ResultsRibsSensitivity and SpecificityTechnetium Tc 99m MedronateJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D S Fernandes, R W Aye, D J Garnett, J Denny. 2000. Target-specific rib biopsy using the gamma probe.. https://doi.org/10.1016/s0002-9610(00)00364-0

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.

BACKGROUND: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of incisional biopsies on melanoma patient survival has been discussed for many years. This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival. METHODS: After (partial) removal of a pigmented skin lesion 471 patients were diagnosed with stage I/II melanoma and underwent re-excision and a sentinel node biopsy. All patients were followed prospectively, mean follow up >5 years. Patients were divided according to their diagnostic biopsy type (wide excision biopsy, narrow excision biopsy, excision biopsy with positive margins and incisional biopsy) and the presence of residual tumor cells in their re-excision specimen. Survival analysis was done using Cox's proportional hazard model adjusted for eight important confounders of melanoma patient survival. RESULTS: The diagnostic biopsy was wide in 279 patients, narrow in 109 patients, 52 patients underwent an excision biopsy with positive margins and 31 patients an incisional biopsy. In 41 patients residual tumor cells were present in the re-excision specimen. Both the diagnostic biopsy type and the presence of tumor cells in the re-excision specimen did not influence disease free and overall survival of melanoma patients. CONCLUSIONS: Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.

Biopsy↗