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PubMed · 10932032

Evidence that a decrease in liver glycogen content stimulates FFA mobilization during exercise.

K Couturier·P Bélanger·M G Latour·J M Lavoie
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Abstract

This study evaluated a liver glycogen content decrease before exercise on the metabolic responses during exercise. Rats injected with glucagon (20 microg x kg(-1)) were compared to rats with a 50% food restriction (1/2-fast) and normally fed rats. All were studied at rest and during exercise (26 m/min, 0% grade). Resting liver glycogen concentrations were twice as high (P<.01) in normally fed rats, with no significant differences between 1/2-fast and glucagon-injected rats. During exercise, liver glycogen content was significantly reduced in normally fed rats. After exercise, plasma insulin levels were decreased (P<.01) in all groups, and beta-hydroxybutyrate concentrations were similar in normally fed and glucagon-injected rats and significantly (P<.01) lower in 1/2-fast rats. Exercise caused a significant increase in FFA concentrations in all groups (P<.01). No significant differences in FFA concentrations were found between 1/2-fast and glucagon-injected groups (P>0.05).

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Analysis of VarianceAnimalsBlood GlucoseFastingFatty Acids, NonesterifiedGlucagonInsulinLiverLiver GlycogenMaleMuscle, SkeletalPhysical Conditioning, AnimalRatsRats, Sprague-DawleyComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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K Couturier, P Bélanger, M G Latour, J M Lavoie. 2000. Evidence that a decrease in liver glycogen content stimulates FFA mobilization during exercise.. https://doi.org/10.1139/h00-010

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