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PubMed · 10935554

Left ventricular assist device-induced reverse ventricular remodeling.

D Burkhoff·J W Holmes·J Madigan·A Barbone·M C Oz
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Abstract

Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart failure), improved baseline contractility, and improved contractile response to increased heart rate and to beta-agonist stimulation. These findings indicate the profound degree of recovery of myocardial properties in hearts previously considered to have invincible end-stage heart failure.

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CalciumCalcium-Transporting ATPasesEchocardiographyHeart FailureHeart VentriclesHeart-Assist DevicesHumansMyocardial ContractionMyocardiumSodium-Calcium ExchangerVentricular PressureVentricular RemodelingJournal ArticleReview

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BibTeXRIS

D Burkhoff, J W Holmes, J Madigan, A Barbone, M C Oz. Left ventricular assist device-induced reverse ventricular remodeling.. https://doi.org/10.1053/pcad.2000.7190

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