Third-generation thrombolytic drugs.

M Verstraete

doi:10.1016/s0002-9343(00)00380-6

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PubMed · 10936478

Third-generation thrombolytic drugs.

M Verstraete

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Abstract

Several third-generation thrombolytic agents have been developed. They are either conjugates of plasminogen activators with monoclonal antibodies against fibrin, platelets, or thrombomodulin; mutants, variants, and hybrids of alteplase and prourokinase (amediplase); or new molecules of animal (vampire bat) or bacterial (Staphylococcus aureus) origin. These variations may lengthen the drug's half-life, increase resistance to plasma protease inhibitors, or cause more selective binding to fibrin. Compared with the second-generation agent (alteplase), third-generation thrombolytic agents such as monteplase, tenecteplase, reteplase, lanoteplase, pamiteplase, and staphylokinase result in a greater angiographic patency rate in patients with acute myocardial infarction, although, thus far, mortality rates have been similar for those few drugs that have been studied in large-scale trials. Bleeding risk, however, may be greater.

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Clinical Trials as Topic Drug Evaluation Fibrin Fibrinolytic Agents Half-Life Humans Myocardial Ischemia Plasminogen Activators Thrombolytic Therapy Thrombomodulin Journal Article Review

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M Verstraete. 2000. Third-generation thrombolytic drugs.. https://doi.org/10.1016/s0002-9343(00)00380-6

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