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PubMed · 10946236

The BRCA1 C-terminal domain: structure and function.

T Huyton·P A Bates·X Zhang·M J Sternberg·P S Freemont
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Abstract

The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules.

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Amino Acid SequenceBRCA1 ProteinBacterial ProteinsBiopolymersBreast NeoplasmsCarrier ProteinsCell Cycle ProteinsDNA DamageDNA LigasesDNA NucleotidylexotransferaseDNA RepairDNA-Binding ProteinsEvolution, MolecularFemaleFungal ProteinsGenes, BRCA1HumansModels, MolecularMolecular Sequence DataMutation, MissenseNeoplastic Syndromes, HereditaryNuclear ProteinsPoly(ADP-ribose) PolymerasesProtein ConformationProtein Structure, TertiarySequence AlignmentSequence Homology, Amino AcidStructure-Activity RelationshipTumor Suppressor ProteinsUbiquitin-Protein LigasesX-ray Repair Cross Complementing Protein 1Comparative StudyJournal Article

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T Huyton, P A Bates, X Zhang, M J Sternberg, P S Freemont. 2000-08-30. The BRCA1 C-terminal domain: structure and function.. https://doi.org/10.1016/s0921-8777(00)00034-3

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Amino Acid Sequence↗
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Amino Acid Sequence↗
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Amino Acid Sequence↗