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PubMed · 10952215

Sectorial mutagenesis by transposable elements.

J Jurka·V V Kapitonov
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Abstract

Transposable elements (TEs) generate insertions and cause other mutations in the genomic DNA. It is proposed that during co-evolution between TEs and eukaryotic genomes, an optimal path of the insertion mutagenesis is determined by the surviving TEs. These TEs can become semi-permanently established, chromatin-regulated 'source' or 'mutator genes', responsible for targeting insertion mutations to specific chromosomal regions. Such mutations can manifest themselves in non-random distribution patterns of interspersed repeats in eukaryotic chromosomes. In this paper we discuss specific models,examples and implications of optimized mutagenesis in eukaryotes.

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Base SequenceChromosomesDNADNA Transposable ElementsMolecular Sequence DataMutagenesisPhylogenySequence Homology, Nucleic AcidJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J Jurka, V V Kapitonov. 1999. Sectorial mutagenesis by transposable elements.. https://pubmed.ncbi.nlm.nih.gov/10952215/

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