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PubMed · 10955985

Soluble polymer-supported organic synthesis.

P H Toy·K D Janda
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Abstract

Soluble polymers have been used as supports for reagent/catalyst immobilization and synthesis. Two polymers are commonly used in this context, linear polystyrene and poly(ethylene glycol). The complementary solubility properties of these polymers allow access to a wide range of chemistries. Parallel and combinatorial libraries of small molecules have been prepared using these polymers, and reagents/catalysts that are easily recovered and recycled have been immobilized on them. To develop soluble polymers with novel properties, bifunctional polymerization initiators have been used in a parallel combinatorial methodology to prepare block copolymers that exhibit unique solubility profiles.

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Indicators and ReagentsOrganic ChemicalsPolymersSolubilityJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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P H Toy, K D Janda. 2000. Soluble polymer-supported organic synthesis.. https://doi.org/10.1021/ar990140h

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