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PubMed · 10961924

Co-repressor complexes and remodelling chromatin for repression.

A P Wolffe·F D Urnov·D Guschin
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Abstract

Recent progress identifies targeted chromatin remodelling by co-repressor complexes as being an integral component of transcriptional silencing. Here we discuss how chromatin structure and the basal transcriptional machinery are manipulated by the co-repressor complex containing the Mi-2 nucleosomal ATPase, the histone-binding protein RbAp48 and histone deacetylase and by the co-repressor complex containing SIN3, RbAp48 and histone deacetylase. Remarkably, both of these complexes also contain methyl-CpG-binding proteins. This observation provides a molecular mechanism to integrate DNA methylation fully into gene control in vertebrates.

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Adenosine TriphosphatasesAnimalsCarrier ProteinsChromatinChromosomal Proteins, Non-HistoneChromosomesCpG IslandsDNA MethylationGene SilencingHistone DeacetylasesHistonesHumansModels, BiologicalNuclear ProteinsNucleosomesReceptors, SteroidRepressor ProteinsRetinoblastoma-Binding Protein 4Saccharomyces cerevisiae ProteinsTranscription FactorsTranscription, GeneticTranscriptional ActivationJournal ArticleReview

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A P Wolffe, F D Urnov, D Guschin. 2000. Co-repressor complexes and remodelling chromatin for repression.. https://pubmed.ncbi.nlm.nih.gov/10961924/

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