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PubMed · 10966865

Intercellular junctions: downstream and upstream of Ras?

J A Mercer
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Abstract

Most human tumors are of epithelial origin, and these tumors gradually lose their epithelial character in a process termed the epithelial-mesenchymal transition. Approximately 40% of human tumors have activating mutations in one of the three RAS genes. Given these statistics, it is critically important to understand the role of Ras signaling in the epithelial-mesenchymal transition. This review considers the mechanisms and effectors through which Ras may regulate intercellular junction formation in epithelial cells. Conversely, intercellular junction proteins themselves may play a role in regulating Ras activation and signaling.

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AnimalsDrosophilaEpithelial CellsFemaleGene Expression Regulation, NeoplasticGenes, rasHumansIntercellular JunctionsKinesinsMicrofilament ProteinsModels, BiologicalMutationMyosinsNeoplasmsRetinal Cone Photoreceptor CellsSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J A Mercer. 2000. Intercellular junctions: downstream and upstream of Ras?. https://doi.org/10.1006/scdb.2000.0181

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