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PubMed · 10967251

Relatedness testing in subdivided populations.

K L Ayres
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Abstract

Assigning probabilities to alleged relationships, given DNA profiles, requires, among other things, calculation of a likelihood ratio (LR). Such calculations usually assume independence of genes: this assumption is not appropriate when the tested individuals share recent ancestry due to population substructure. Adjusted LR formulae, incorporating the coancestry coefficient F(ST), are presented here for various two-person relationships, and the issue of mutations in parentage testing is also addressed.

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FamilyFemaleGenetics, PopulationGenotypeHumansLikelihood FunctionsMaleMutationPaternityJournal Article

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K L Ayres. 2000-11-13. Relatedness testing in subdivided populations.. https://doi.org/10.1016/s0379-0738(00)00289-9

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