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PubMed · 1096975

Selective IgA deficiency---some perspectives.

S Horowitz·R Hong
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Abstract

The clinical spectrum of IgA deficiency varies from good health to respiratory, gastrointestinal, autoimmune and malignant disorders. Evaluation of B lymphocytes with surface IgA receptors in this disease reveals cap formation, decreased to normal density of IgA receptors, and IgA secretion following pokeweed stimulation. Further study of antigen-induced B-lymphocyte phenomena is needed. The presence of decreased numbers of T-cell markers in some individuals with IgA deficiency suggests a T-"helper" cell defect.

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Antibody FormationAntigensAsthmaAutoimmune DiseasesB-LymphocytesBinding Sites, AntibodyCeliac DiseaseEndocytosisEpithelial CellsEpitheliumFluorescent Antibody TechniqueGastrointestinal DiseasesHumansIgA DeficiencyImmunoglobulin EImmunoglobulin GImmunoglobulin MMacrophagesNeoplasmsOncogenic VirusesRespiratory Tract InfectionsRhinitis, Allergic, SeasonalT-LymphocytesJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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S Horowitz, R Hong. 1975. Selective IgA deficiency---some perspectives.. https://pubmed.ncbi.nlm.nih.gov/1096975/

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