The quantification of technetium in generator-derived pertechnetate using ICP-MS.

D M Hill; R K Barnes; H K Wong; A W Zawadzki

doi:10.1016/s0969-8043(99)00280-8

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The quantification of technetium in generator-derived pertechnetate using ICP-MS.

D M Hill·R K Barnes·H K Wong·A W Zawadzki

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Abstract

Previous analytical methods employed to measure 99Tc:99mTc ratios in chromatographic 99mTc generators, derived from fission-based 99Mo, were limited in monitoring the ratios in low activity generators, over the extent of their elution regimes. For regulatory purposes, ICP-MS was employed to measure total technetium in generator eluates down to a level of 200 pg ml(-1) (200 ppt). Measured 99Tc:99mTc ratios compared very well with the theoretically computed values, ranging from 47:1 for a first elution of a generator with a long ingrowth time to 1.4:1 for the 17th elution of a generator with a short ingrowth time.

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Calibration Chromatography, Ion Exchange Gamma Rays Mass Spectrometry Sodium Pertechnetate Tc 99m Technetium Journal Article

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D M Hill, R K Barnes, H K Wong, A W Zawadzki. 2000. The quantification of technetium in generator-derived pertechnetate using ICP-MS.. https://doi.org/10.1016/s0969-8043(99)00280-8

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