Conformational diffusion and helix formation kinetics.

G Hummer; A E García; S Garde

doi:10.1103/physrevlett.85.2637

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Conformational diffusion and helix formation kinetics.

G Hummer·A E García·S Garde

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Abstract

The time, temperature, and sequence dependences of helix formation kinetics of fully atomistic peptide models in explicit solvent are described quantitatively by a diffusive search within the coil state with barrierless transitions into the helical state. Conformational diffusion leads to nonexponential kinetics and jump-width dependences in temperature jump experiments.

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Kinetics Models, Theoretical Peptides Protein Conformation Protein Structure, Secondary Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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G Hummer, A E García, S Garde. 2000-09-18. Conformational diffusion and helix formation kinetics.. https://doi.org/10.1103/physrevlett.85.2637

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