Does ADMA cause endothelial dysfunction?

J P Cooke

doi:10.1161/01.atv.20.9.2032

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PubMed · 10978245

Does ADMA cause endothelial dysfunction?

J P Cooke

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Abstract

Asymmetric dimethylarginine (ADMA) is an endogenous and competitive inhibitor of nitric oxide synthase. Plasma levels of this inhibitor are elevated in patients with atherosclerosis and in those with risk factors for atherosclerosis. In these patients, plasma ADMA levels are correlated with the severity of endothelial dysfunction and atherosclerosis. By inhibiting the production of nitric oxide, ADMA may impair blood flow, accelerate atherogenesis, and interfere with angiogenesis. ADMA may be a novel risk factor for vascular disease.

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Amidohydrolases Arginine Arteriosclerosis Endothelium, Vascular Homeostasis Humans Hydrolases Neovascularization, Physiologic Nitric Oxide Nitric Oxide Synthase Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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J P Cooke. 2000. Does ADMA cause endothelial dysfunction?. https://doi.org/10.1161/01.atv.20.9.2032

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