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PubMed · 10981029

Update on Clostridium difficile infection.

C S Alcantara·R L Guerrant
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Abstract

Clostridium difficile is a major cause of antibiotic-associated diarrhea in hospital and community settings, spreading endemic and epidemic disease in developed and developing areas throughout the world. Its toxins A and B cause epithelial disruption, inflammation, and secretion. Diagnosis of infection with C. difficile is based on appropriate clinical presentation and demonstration of the presence of either toxin A or B, or both. Established treatment is still predominantly metronidazole and vancomycin. The association of antibiotic therapy with recurrent disease and antimicrobial resistance, especially vancomycin-resistant enterococci, highlights the need for new approaches to managing C. difficile infection.

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Anti-Bacterial AgentsAnti-Infective AgentsCommunity-Acquired InfectionsDisease OutbreaksEnterocolitis, PseudomembranousHumansMetronidazoleRecurrenceVancomycinJournal ArticleReview

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C S Alcantara, R L Guerrant. 2000. Update on Clostridium difficile infection.. https://doi.org/10.1007/s11894-000-0024-x

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