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PubMed · 10981503

Serotonin and pancreatic duct function.

S Naruse·A Suzuki·H Ishiguro·M Kitagawa·S B Ko·T Yoshikawa·A Yamamoto·H Hamada·T Hayakawa
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Abstract

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

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5-MethoxytryptamineAcetylcholineAnimalsCalciumGuinea PigsPancreatic DuctsSecretinSerotoninVasodilator AgentsJournal Article

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S Naruse, A Suzuki, H Ishiguro, M Kitagawa, S B Ko, T Yoshikawa, A Yamamoto, H Hamada, T Hayakawa. 2000. Serotonin and pancreatic duct function.. https://doi.org/10.3346/jkms.2000.15.s.s27

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