Engineering therapeutic proteins.

J McCafferty; D R Glover

doi:10.1016/s0959-440x(00)00108-1

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PubMed · 10981628

Engineering therapeutic proteins.

J McCafferty·D R Glover

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Abstract

Many early drug candidates derived from biotechnology failed in clinical trials because of their low affinity/specificity, short half-lives or immunogenicity. Protein engineering techniques have been applied to circumvent some of the problems that hindered these earlier trials, resulting in clinical benefits from a range of engineered antibodies and other proteins.

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Animals Drug Design Humans Protein Engineering Proteins Structure-Activity Relationship Journal Article Review

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J McCafferty, D R Glover. 2000. Engineering therapeutic proteins.. https://doi.org/10.1016/s0959-440x(00)00108-1

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