Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.

E Gelens; W J Koot; W M Menge; H C Ottenheijm; H Timmerman

doi:10.1016/s0960-894x(00)00363-2

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Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.

E Gelens·W J Koot·W M Menge·H C Ottenheijm·H Timmerman

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Abstract

Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles.

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E Gelens, W J Koot, W M Menge, H C Ottenheijm, H Timmerman. 2000-09-04. Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.. https://doi.org/10.1016/s0960-894x(00)00363-2

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