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PubMed · 10987431

Solid-phase synthesis of acridine-based threading intercalator peptides.

C B Carlson·P A Beal
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Abstract

The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding.

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AcridinesDNAIntercalating AgentsPeptidesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

C B Carlson, P A Beal. 2000-09-04. Solid-phase synthesis of acridine-based threading intercalator peptides.. https://doi.org/10.1016/s0960-894x(00)00388-7

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