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PubMed · 10987721

Cholera vaccines.

E T Ryan·S B Calderwood
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Abstract

Cholera causes significant morbidity and mortality worldwide. For travelers, the risk of developing cholera per month of stay in a developing country is approximately 0.001%-0.01%, and cholera may present as traveler's diarrhea. In the United States, only a poorly tolerated, marginally effective, parenterally administered, phenol-inactivated vaccine is available. Outside the United States, 2 additional vaccines are commercially available: an oral killed whole cell-cholera toxin recombinant B subunit vaccine (WC-rBS) and an oral live attenuated Vibrio cholerae vaccine (CVD 103-HgR). These oral vaccines are well tolerated. In field trials, WC-rBS provides 80%-85% protection from cholera caused by V. cholerae serogroup O1 for at least 6 months. In volunteer studies, CVD 103-HgR provides 62%-100% protection against cholera caused by V. cholerae for at least 6 months. No commercially available cholera vaccine protects against disease caused by V. cholerae serogroup O139. New cholera vaccines are being developed.

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CholeraCholera ToxinCholera VaccinesHumansImmunization ScheduleTravelVaccines, AttenuatedVaccines, SubunitVaccines, SyntheticVibrio choleraeJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

E T Ryan, S B Calderwood. 2000-09-07. Cholera vaccines.. https://doi.org/10.1086/313951

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