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Risperidone augmentation in refractory obsessive-compulsive disorder: an open-label study.

C Pfanner·D Marazziti·L Dell'Osso·S Presta·A Gemignani·A Milanfranchi·G B Cassano
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Abstract

Risperidone, an atypical neuroleptic, has been proposed for augmentation strategies in resistant obsessive-compulsive disorder (OCD). We report the results of an open-label trial on the use of the combination of serotonin reuptake inhibitors (SRIs) with risperidone in 20 refractory OCD outpatients. All patients had been suffering from OCD, according to DSM-IV criteria, for at least 2 years and had various comorbid disorders. All had been treated with a SRI at adequate dosages for at least 6 months, but had failed to respond. Therefore, risperidone was added and the dosage titrated up to the mean dose of 3 mg/day over 8 weeks. After 2 months of this regimen, all patients had shown a reduction in obsessive-compulsive symptoms, as assessed by the decrease in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) total score, particularly those with a lifetime comorbidity with bipolar disorder; only three patients reported mild sedation and postural hypotension, two mild extrapyramidal side-effects (tremors and akatysia) and two an increased appetite. All these effects were well tolerated and no patient halted the treatment. The addition of risperidone would appear to be a useful strategy for augmenting SRI effectiveness in refractory OCD patients.

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AdultAntipsychotic AgentsBipolar DisorderComorbidityDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderRecurrenceRisperidoneSelective Serotonin Reuptake InhibitorsTreatment OutcomeClinical TrialJournal Article

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C Pfanner, D Marazziti, L Dell'Osso, S Presta, A Gemignani, A Milanfranchi, G B Cassano. 2000. Risperidone augmentation in refractory obsessive-compulsive disorder: an open-label study.. https://doi.org/10.1097/00004850-200015050-00007

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