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PubMed · 10993289

Interleukin-6 signal transduction and lymphocyte function.

F Horn·C Henze·K Heidrich
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Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine that acts on a wide variety of cell types. It has important regulatory functions in the immune system, is a mediator of the acute-phase response, and is involved in the regulation of differentiation, proliferation, and survival of target cells. A major signal transduction pathway for IL-6 involves activation of JAK kinases and the transcription factor Stat3. In addition, a great many of other signalling pathways are induced. Stat3 has been shown to be a central player of IL-6 signalling in many systems whereas the functions of most other IL-6-activated pathways are not yet understood. In this review, we discuss the current knowledge on IL-6 functions in the immune system, IL-6 signal transduction, and its significance for lymphocyte function.

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AnimalsB-LymphocytesDNA-Binding ProteinsHumansImmune SystemInterleukin-6Janus Kinase 1Janus Kinase 2Protein-Tyrosine KinasesProto-Oncogene ProteinsReceptors, Interleukin-6STAT3 Transcription FactorSignal TransductionT-LymphocytesTrans-ActivatorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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F Horn, C Henze, K Heidrich. 2000. Interleukin-6 signal transduction and lymphocyte function.. https://doi.org/10.1016/s0171-2985(00)80061-3

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