Perspectives for vascular genomics.

E M Rubin; A Tall

doi:10.1038/35025236

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PubMed · 11001070

Perspectives for vascular genomics.

E M Rubin·A Tall

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Abstract

Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- and intraspecies sequence comparisons, genotyping with dense marker sets spanning the genome, large-scale mutagenesis screens of model organisms, and genome-wide expression profiling have all begun to contribute to the identification of new genes and mechanisms that are central to cardiovascular disease processes.

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Animals Cardiovascular Diseases Cardiovascular Physiological Phenomena Forecasting Gene Expression Profiling Gene Expression Regulation Genome, Human Humans Mutagenesis Polymorphism, Genetic Sequence Analysis, DNA Journal Article Review

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E M Rubin, A Tall. 2000-09-14. Perspectives for vascular genomics.. https://doi.org/10.1038/35025236

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