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PubMed · 11006539

Force spectroscopy with single bio-molecules.

H Clausen-Schaumann·M Seitz·R Krautbauer·H E Gaub
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Abstract

For many biological molecules, force is an important functional and structural parameter. With the rapidly growing knowledge about the relation between structure, function, and force, single-molecule force spectroscopy has become a versatile analytical tool for the structural and functional investigation of single bio-molecules in their native environments. Within the past year, detailed insights into binding potentials of receptor ligand pairs, protein folding pathways, molecular motors, DNA mechanics and the functioning of DNA-binding agents (such as proteins and drugs), as well as the function of molecular motors, have been obtained.

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DNAProtein FoldingSpectrum AnalysisJournal ArticleResearch Support, Non-U.S. Gov'tReview

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H Clausen-Schaumann, M Seitz, R Krautbauer, H E Gaub. 2000. Force spectroscopy with single bio-molecules.. https://doi.org/10.1016/s1367-5931(00)00126-5

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