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PubMed · 11009084

Study of the B cell memory compartment in common variable immunodeficiency.

J C Brouet·A Chedeville·J P Fermand·B Royer
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Abstract

We evaluated the B cell memory pool among blood B cells from 20 patients with common variable immunodeficiency (CVID). CD27+ B cell number was normal or increased in 6 patients (with 95% CD27+ B cells in 1 patient) and decreased in 14 patients. In 13 or 15 patients studied, the CD27 molecule was detectable on less than 50% IgG or IgA B cells, indicating a defect in the maturation of these memory cells. Within the group of patients with a low number of CD27+ B cells, no up-regulation of this molecule was observed after in vitro stimulation of purified B cells from 3 of 5 patients studied, suggesting an intrinsic B cell defect. In addition, ligation of the CD27 molecule was unable to trigger terminal differentiation of purified B cells in 1 of 2 cases with a large number of CD27+ B cells. Finally, the CD27 ligand was normally expressed on activated T cells in only 5 of 14 patients studied. These data confirm the heterogeneity of immunological defects in patients with CVID. Abnormal expression and/or function of the CD27-CD70 members of the TNF/TNF receptor family contribute to the immunological defect.

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Antigens, CDB-LymphocytesCD27 LigandCD3 ComplexCell DifferentiationCommon Variable ImmunodeficiencyHumansImmunologic MemoryLymphocyte ActivationMembrane ProteinsT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 7Journal Article

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J C Brouet, A Chedeville, J P Fermand, B Royer. 2000. Study of the B cell memory compartment in common variable immunodeficiency.. https://doi.org/10.1002/1521-4141(200009)30%3A9%3C2516%3A%3Aaid-immu2516%3E3.0.co%3B2-z

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