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PubMed · 11014943

Changes in plasma adenosine concentrations during normal pregnancy.

Y Yoneyama·S Suzuki·R Sawa·T Takeuchi·H Kobayashi·R Takei·Y Kiyokawa·Y Otsubo·Z Hayashi·T Araki
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Abstract

The aim of this study was to measure changes in plasma adenosine concentration [ADO] during a normal pregnancy and to evaluate the possible role of platelets and red blood cells (RBC) as causes of changes in plasma [ADO]. We measured the plasma [ADO] in normal pregnant women (n = 11) during the first, second and third trimesters. The mean plasma [ADO] in the third trimester was 0.41 +/- 0.08 microM (means +/- SEM), significantly higher than in the first and second trimesters (p < 0.05). In pregnant women, platelet and RBC counts, hematocrit and hemoglobin concentration decreased slightly throughout the pregnancy. The elevation in the plasma [ADO] correlated inversely with the platelet count (r = -0.43, p < 0.05). These results suggest that an increase in the plasma [ADO] in the third trimester may be attributed to the enhanced adenosine release from activated platelets.

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AdenosineAdultErythrocyte CountFemaleHematocritHemoglobinsHumansPlatelet CountPregnancyPregnancy TrimestersJournal Article

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Y Yoneyama, S Suzuki, R Sawa, T Takeuchi, H Kobayashi, R Takei, Y Kiyokawa, Y Otsubo, Z Hayashi, T Araki. 2000. Changes in plasma adenosine concentrations during normal pregnancy.. https://doi.org/10.1159/000010313

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