Parvovirus-mediated antineoplastic activity exploits genome instability.

F F Shadan; L P Villarreal

doi:10.1054/mehy.1999.0887

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Parvovirus-mediated antineoplastic activity exploits genome instability.

F F Shadan·L P Villarreal

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Abstract

The generation and accumulation of genetic mutations have been associated with carcinogenesis. Epidemiological and experimental evidence implicate parvoviruses in growth inhibition (oncosuppression) and selective destruction (oncolysis) of tumor cells. It is proposed here that parvoviruses can preferentially target genetically unstable tumor cells, which are deficient in DNA repair mechanisms. This selective strategy may serve as a virus-based therapeutic approach against cancer.

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Animals Humans Neoplasms Parvoviridae Infections Parvovirus Tumor Cells, Cultured Journal Article

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F F Shadan, L P Villarreal. 2000. Parvovirus-mediated antineoplastic activity exploits genome instability.. https://doi.org/10.1054/mehy.1999.0887

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