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PubMed · 11028817

A rippled-pattern trichoblastoma: an immunohistochemical study.

O Yamamoto·M Hisaoka·H Yasuda·D Nishio·M Asahi
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Abstract

BACKGROUND: Since the first description by Hashimoto et al., there have been only a few case reports of rippled-pattern tricogenic tumor. In addition, there are no reports on detailed immunohistochemical analyses of this rare neoplasm. We describe here an additional case of rippled-pattern trichogenic tumor with a special reference to its immunohistochemical features. METHODS: A nodule arising on the occipital area of a 62-year-old Japanese woman was histologically and immunohistochemically investigated. RESULTS: Histopathologically, the lesion contained various-sized lobular nests, which consisted of oval to elliptical shaped basaloid cells without any atypia and were embedded in the collagenous stroma. Some elongated basaloid cells were arranged in a palisading fashion forming parallel rows of epithelial ribbons in a rippled-pattern. Cytokeratin (CK) immunohistochemistry showed constant expressions of CK1/5/ 10/14, CK5/8, CK14 and CK7, and focal expressions of CK17 and CK19 in the basaloid cells, suggesting a keratin phenotypical similarity to the cells in small nodular type trichoblastoma. CONCLUSIONS: The present tumor is a variant of trichoblastoma, and considered to be in close association with the outer root sheath and/ or follicular germinative cells.

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Biomarkers, TumorFemaleHair DiseasesHair FollicleHumansImmunoenzyme TechniquesKeratinsMiddle AgedNeoplasm ProteinsNeoplasms, Basal CellSkin NeoplasmsCase ReportsJournal Article

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O Yamamoto, M Hisaoka, H Yasuda, D Nishio, M Asahi. 2000. A rippled-pattern trichoblastoma: an immunohistochemical study.. https://doi.org/10.1034/j.1600-0560.2000.027009460.x

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