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Logical computation using algorithmic self-assembly of DNA triple-crossover molecules.

C Mao·T H LaBean·J H Relf·N C Seeman
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Abstract

Recent work has demonstrated the self-assembly of designed periodic two-dimensional arrays composed of DNA tiles, in which the intermolecular contacts are directed by 'sticky' ends. In a mathematical context, aperiodic mosaics may be formed by the self-assembly of 'Wang' tiles, a process that emulates the operation of a Turing machine. Macroscopic self-assembly has been used to perform computations; there is also a logical equivalence between DNA sticky ends and Wang tile edges. This suggests that the self-assembly of DNA-based tiles could be used to perform DNA-based computation. Algorithmic aperiodic self-assembly requires greater fidelity than periodic self-assembly, because correct tiles must compete with partially correct tiles. Here we report a one-dimensional algorithmic self-assembly of DNA triple-crossover molecules that can be used to execute four steps of a logical (cumulative XOR) operation on a string of binary bits.

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AlgorithmsComputational BiologyDNANucleic Acid ConformationJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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C Mao, T H LaBean, J H Relf, N C Seeman. 2000-09-28. Logical computation using algorithmic self-assembly of DNA triple-crossover molecules.. https://doi.org/10.1038/35035038

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