DNA fragmentation in apoptosis.

J H Zhang; M Xu

doi:10.1038/sj.cr.7290049

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PubMed · 11032172

DNA fragmentation in apoptosis.

J H Zhang·M Xu

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Abstract

Cleavage of chromosomal DNA into oligonucleosomal size fragments is an integral part of apoptosis. Elegant biochemical work identified the DNA fragmentation factor (DFF) as a major apoptotic endonuclease for DNA fragmentation in vitro. Genetic studies in mice support the importance of DFF in DNA fragmentation and possibly in apoptosis in vivo. Recent work also suggests the existence of additional endonucleases for DNA degradation. Understanding the roles of individual endonucleases in apoptosis, and how they might coordinate to degrade DNA in different tissues during normal development and homeostasis, as well as in various diseased states, will be a major research focus in the near future.

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Animals Apoptosis Apoptosis Regulatory Proteins Caspases Chromosomes DNA Fragmentation Endonucleases Humans Proteins Journal Article Research Support, U.S. Gov't, P.H.S.Review

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J H Zhang, M Xu. 2000. DNA fragmentation in apoptosis.. https://doi.org/10.1038/sj.cr.7290049

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