Na(+)-Ca(2+) exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development.

M Sakaue; H Nakamura; I Kaneko; Y Kawasaki; N Arakawa; H Hashimoto; Y Koyama; A Baba; T Matsuda

doi:10.1016/s0006-8993(00)02808-0

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Na(+)-Ca(2+) exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development.

M Sakaue·H Nakamura·I Kaneko·Y Kawasaki·N Arakawa·H Hashimoto·Y Koyama·A Baba·T Matsuda

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Abstract

We examined the relative amounts of Na(+)-Ca(2+) exchanger (NCX) isoform mRNAs in cultured neurons, astrocytes and developmental rat brain. NCX1 transcript was predominant in neurons and astrocytes, but NCX2 transcript was about four-fold higher than NCX1 or NCX3 transcript in adult rat cortex. NCX2 transcript in the cortex increased markedly during postnatal development, whereas NCX1 and NCX3 transcripts decreased. Na(+)-dependent 45Ca(2+) uptake in the cortical homogenate increased significantly during postnatal development.

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Animals Animals, Newborn Astrocytes Cells, Cultured Cerebral Cortex Membrane Transport Proteins Neurons Protein Isoforms RNA, Messenger Rats Sodium-Calcium Exchanger Journal Article Research Support, Non-U.S. Gov't

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M Sakaue, H Nakamura, I Kaneko, Y Kawasaki, N Arakawa, H Hashimoto, Y Koyama, A Baba, T Matsuda. 2000-10-27. Na(+)-Ca(2+) exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development.. https://doi.org/10.1016/s0006-8993(00)02808-0

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