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Variance component methods for detecting complex trait loci.

J Blangero·J T Williams·L Almasy
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Abstract

Variance component-based linkage analysis has become a major statistical tool for the localization and evaluation of quantitative trait loci influencing complex phenotypes. The variance component approach has many benefits--it can, for example, be used to analyze large pedigrees, and it is able to accommodate multiple loci simultaneously in a true oligogenic model. Important biological phenomena such as genotype-environment interaction and epistasis are also examined easily in a variance component framework. In this chapter, we review the basic statistical features of variance component linkage analysis, with an emphasis on its power and robustness to distributional violations.

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Analysis of VarianceChromosome MappingGenetic LinkageGenotypeHumansLikelihood FunctionsModels, TheoreticalMolecular EpidemiologyMultivariate AnalysisNuclear FamilyPhenotypeQuantitative Trait, HeritableComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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J Blangero, J T Williams, L Almasy. 2001. Variance component methods for detecting complex trait loci.. https://doi.org/10.1016/s0065-2660(01)42021-9

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